DNLI — Denali Therapeutics Inc.

Nasdaq · Health Care · Biotechnology · CIK 1714899 ·
Last close
$24.20
Market Cap
$3.87B
52W High
$27.30
52W Low
$18.60
ADV30
1,541,064
Next earnings
2026-11-05
Denali Therapeutics Inc., a biopharmaceutical company, discovers and develops therapeutics to treat neurodegenerative and lysosomal storage diseases. The company develops Eclitasertib (SAR443122/DNL758) RIPK1 inhibitor program for peripheral inflammatory diseases; BIIB122/DNL151 LRRK2 inhibitor program for Parkinson's disease; TAK-594/DNL593 program for frontotemporal dementia-granulin; DNL126 program for MPS IIIA (Sanfilippo Syndrome A); and DNL310 Tividenofusp alfa, an enzyme replacement therapy program for MPS II (Hunter Syndrome). Its Enzyme TransportVehicle (TV) programs include DNL952 for the treatment of Pompe disease; DNL111 for Parkinson's and Gaucher diseases; and DNL622 for Hurler syndrome (MPS I). The company's OTV programs also comprise DNL628 targeting tau for Alzheimer's disease; and DNL422 targeting alpha synuclein for Parkinson's disease, as well as antibody TV program includes DNL921 targeting Abeta for treating Alzheimer's disease. The company was formerly known as SPR Pharma Inc. and changed its name to Denali Therapeutics Inc. in March 2015. Denali Therapeutics Inc. was incorporated in 2013 and is headquartered in South San Francisco, California.

Quarterly Fundamentals

Revenues vs Net Income (last 4 Q)

Assets vs Liabilities (last 4 Q)

PeriodRevenuesGrossProfit OpIncomeNetIncomeAssets CashLiabilities
Jun 2026 3,604,000 3,511,000 -130,541,000 -127,553,000 1,157,955,000 201,530,000 322,777,000
Mar 2026 0 -137,357,000 -128,447,000 1,266,023,000 387,626,000 339,925,000
Dec 2025 0 -137,365,000 -128,549,000 1,144,854,000 205,326,000 131,093,000
Sep 2025 0 -137,434,000 -126,902,000 1,055,621,000 90,963,000 129,424,000

Cashflow TTM (yfinance, fills SEC gap)

Operating CF
$-434,040,000
Investing CF
$68,980,000
Financing CF
$425,383,000
CapEx
$-37,873,000
Dividends Paid
Buybacks
EPS Diluted TTM
$-2.84
As of
2026-08-09

Balance + Analyst (yfinance extras)

Retained Earnings
$-2,307,524,000
Inventory
$4,139,000
Receivables
$3,927,000
ST Investments
$508,941,000
EBIT TTM
$-542,697,000
Pretax Income TTM
$-511,349,000
Interest Exp TTM
Analysts
16

Yahoo Snapshot (yfinance, live)

Total Revenue
$3,604,000
EBITDA
$-526,057,984
Free Cash Flow
$-268,527,872
Enterprise Value
$3,195,522,048
Total Cash
$710,470,976
Total Debt
$37,686,000
Shares Out
159,847,403
Trailing EPS
$-2.76
Book Value
$5.23
ROE
-54.9%
ROA
-29.1%
Div Yield

Annual Trend (SEC EDGAR, last 4y)

Revenues vs Net Income (last 4y)

FY endRevenuesOpIncome NetIncomeAssetsLiabilities EquityOCF
Dec 2025 0 -555,342,000 -512,540,000 1,144,854,000 131,093,000 -412,600,000
Dec 2024 0 -501,878,000 -422,773,000 1,374,180,000 144,496,000 -347,694,000
Dec 2023 330,531,000 -196,699,000 -145,224,000 1,153,917,000 122,963,000 -357,991,000
Dec 2022 108,463,000 -340,744,000 -325,991,000 1,460,242,000 417,812,000 -244,716,000

TTM Snapshot

Revenues TTM
$10,111,000
NetIncome TTM
$-394,432,000
OpCashFlow TTM
$0
Assets (Latest)
$1,374,180,000
Forward EPS
$-2.43

Max Pain — expiry 2026-09-18

max pain strike: $22.50 · spot: $25.05 · call oi: 1,956 · put oi: 1,618
Expected Move to 2026-09-18: ±$2.33 (9.28%) — implied range $22.72$27.37 · ATM straddle on $25.00 strike

Peers — same industry

TickerNameMarket CapLastDaily %
ADPT Adaptive Biotechnologies Corp $4.08B $25.55
IOVA IOVANCE BIOTHERAPEUTICS, INC. $3.65B $8.06
RLAY Relay Therapeutics, Inc. $4.33B $19.76
TARS Tarsus Pharmaceuticals, Inc. $3.20B $72.81
BEAM Beam Therapeutics Inc. $2.93B $28.33

News headlines (Yahoo Finance, 1h cache)

Denali Therapeutics (DNLI) Q2 2026 Earnings Call Transcript
2026-08-13 22:32 · Yahoo
Denali Therapeutics to Report Second Quarter 2026 Financial Results and Business Highlights on August 6, 2026
2026-07-27 20:01 · Yahoo
Denali Therapeutics to Give Opening Plenary Address at Alzheimer’s Association International Conference (AAIC) 2026 and Highlight Breakthroughs in Delivering Biologic Therapies Across Blood-Brain Barr
2026-07-09 20:01 · Yahoo
Denali Therapeutics Enters Agreement to Sell Rare Pediatric Disease Priority Review Voucher for $195 Million
2026-06-18 12:00 · Yahoo
Denali Therapeutics Inc. Q2 2026 Earnings Call Summary
2026-08-07 12:30 · Yahoo
Will Recent Setbacks Impact Growth Prospects of DNLI Stock?
2026-07-15 17:02 · Yahoo
Denali to Sell Priority Review Voucher for $195M Cash Boost
2026-06-19 12:40 · Yahoo
DNLI Stock Gains 33.1% in Three Months: Buy, Sell or Hold the Stock?
2026-08-20 16:20 · Yahoo
Should You Buy, Sell or Hold Biogen Stock After a 9% Rise in a Month?
2026-08-20 14:12 · Yahoo
DNLI Q2 Loss Narrows, Avlayah Sales Drive Strong Launch Momentum
2026-08-07 18:31 · Yahoo

Recent Insider Activity

No insider activity indexed for this ticker.