DNLI — Denali Therapeutics Inc.

Nasdaq · Health Care · Biotechnology · CIK 1714899 ·
Last close
$19.38
Market Cap
$3.08B
52W High
$23.46
52W Low
$17.71
ADV30
1,734,409
Next earnings
2026-05-11
Denali Therapeutics Inc., a biopharmaceutical company, discovers and develops therapeutics to treat neurodegenerative and lysosomal storage diseases. The company develops Eclitasertib (SAR443122/DNL758) RIPK1 inhibitor program for peripheral inflammatory diseases; BIIB122/DNL151 LRRK2 inhibitor program for Parkinson's disease; TAK-594/DNL593 program for frontotemporal dementia-granulin; DNL126 program for MPS IIIA (Sanfilippo Syndrome A); and DNL310 Tividenofusp alfa, an enzyme replacement therapy program for MPS II (Hunter Syndrome). Its Enzyme TransportVehicle (TV) programs include DNL952 for the treatment of Pompe disease; DNL111 for Parkinson's and Gaucher diseases; and DNL622 for Hurler syndrome (MPS I). The company's OTV programs also comprise DNL628 targeting tau for Alzheimer's disease; and DNL422 targeting alpha synuclein for Parkinson's disease, as well as antibody TV program includes DNL921 targeting Abeta for treating Alzheimer's disease. The company was formerly known as SPR Pharma Inc. and changed its name to Denali Therapeutics Inc. in March 2015. Denali Therapeutics Inc. was incorporated in 2013 and is headquartered in South San Francisco, California.

Quarterly Fundamentals

Revenues vs Net Income (last 4 Q)

Assets vs Liabilities (last 4 Q)

PeriodRevenuesGrossProfit OpIncomeNetIncomeAssets CashLiabilities
Mar 2026 0 -137,357,000 -128,447,000 1,266,023,000 387,626,000 339,925,000
Dec 2025 0 -137,365,000 -128,549,000 1,144,854,000 205,326,000 131,093,000
Sep 2025 0 -137,434,000 -126,902,000 1,055,621,000 90,963,000 129,424,000
Jun 2025 0 -134,963,000 -124,119,000 1,166,241,000 141,207,000 139,188,000

Cashflow TTM (yfinance, fills SEC gap)

Operating CF
$-412,600,000
Investing CF
$255,281,000
Financing CF
$189,216,000
CapEx
$-15,972,000
Dividends Paid
Buybacks
EPS Diluted TTM
$-2.97
As of
2026-05-10

Balance + Analyst (yfinance extras)

Retained Earnings
$-2,051,524,000
Inventory
Receivables
$2,177,000
ST Investments
$662,553,000
EBIT TTM
$-555,342,000
Pretax Income TTM
$-512,438,000
Interest Exp TTM
Analysts
14

Annual Trend (SEC EDGAR, last 4y)

Revenues vs Net Income (last 4y)

FY endRevenuesOpIncome NetIncomeAssetsLiabilities EquityOCF
Dec 2025 0 -555,342,000 -512,540,000 1,144,854,000 131,093,000 -412,600,000
Dec 2024 0 -501,878,000 -422,773,000 1,374,180,000 144,496,000 -347,694,000
Dec 2023 330,531,000 -196,699,000 -145,224,000 1,153,917,000 122,963,000 -357,991,000
Dec 2022 108,463,000 -340,744,000 -325,991,000 1,460,242,000 417,812,000 -244,716,000

TTM Snapshot

Revenues TTM
$10,111,000
NetIncome TTM
$-394,432,000
OpCashFlow TTM
$0
Assets (Latest)
$1,374,180,000
Forward EPS
$-2.49

Peers — same industry

TickerNameMarket CapLastDaily %
BEAM Beam Therapeutics Inc. $3.06B $29.79
RLAY Relay Therapeutics, Inc. $3.04B $14.17
TARS Tarsus Pharmaceuticals, Inc. $2.63B $61.16
TWST Twist Bioscience Corp $4.04B $64.87
ADPT Adaptive Biotechnologies Corp $2.26B $14.13

News headlines (Yahoo Finance, 1h cache)

Denali Therapeutics' Focus Shifts to Other Pipeline Assets After Phase 2b Study Failure, Morgan Stanley Says
2026-05-26 15:29 · Yahoo
Stocks Settle Higher on Iran Peace Hopes and Tech Strength
2026-05-22 20:34 · Yahoo
Biogen Faces Trial Setbacks And Probes That Reframe Neuro Pipeline Risks
2026-05-22 20:15 · Yahoo
Denali Stock Dips as Biogen-Partnered Parkinson's Disease Study Fails
2026-05-22 16:14 · Yahoo
Stocks Climb on US-Iran Peace Hopes and Strength in Chipmakers
2026-05-22 15:20 · Yahoo
Stocks Supported by US-Iran Peace Deal Optimism
2026-05-22 14:13 · Yahoo
Parkinson’s drug from Biogen, Denali comes up short
2026-05-22 10:46 · Yahoo
BIIB, DNLI Stocks Edge Lower After Hours: Parkinson’s Drug Misses Key Goals In Trial
2026-05-21 23:03 · Yahoo
Biogen and Denali Therapeutics Provide Update on Phase 2b LUMA Study of BIIB122 (DNL151) in Early-Stage Parkinson’s Disease
2026-05-21 22:00 · Yahoo
Hedge Fund Wagers $36 Million on Biotech Denali After First FDA Approval
2026-05-18 18:43 · Yahoo

Recent Insider Activity

No insider activity indexed for this ticker.