IONS — IONIS PHARMACEUTICALS INC
—
Nasdaq ·
Health Care ·
Pharmaceuticals ·
CIK 874015 ·
Last close
$44.00
Market Cap
$7.31B
52W High
$86.74
52W Low
$43.01
ADV30
3,824,276
Next earnings
2026-11-04
Quarterly Fundamentals
Revenues vs Net Income (last 4 Q)
Assets vs Liabilities (last 4 Q)
| Period | Revenues | Gross profit | Op income | Net income | Assets | Cash | Liabilities |
|---|---|---|---|---|---|---|---|
| Jun 2026 | — | — | — | — | — | — | — |
| Mar 2026 | 246,091,000 | 243,091,000 | -117,482,000 | -92,528,000 | 3,449,969,000 | 173,381,000 | 2,958,555,000 |
| Dec 2025 | 203,330,000 | 195,373,000 | -214,473,000 | -229,394,000 | 3,523,836,000 | 372,260,000 | 3,034,747,000 |
| Sep 2025 | 156,719,000 | 154,381,000 | -160,173,000 | -128,606,000 | 3,033,091,000 | 338,341,000 | 2,415,124,000 |
Cashflow TTM (yfinance, fills SEC gap)
Operating CF
$-496,434,000
Investing CF
$232,150,000
Financing CF
$317,358,000
CapEx
$-71,070,000
Dividends Paid
—
Buybacks
—
EPS Diluted TTM
$-3.46
As of
2026-08-02
Balance + Analyst (yfinance extras)
Retained Earnings
$-2,838,369,000
Inventory
$50,833,000
Receivables
$58,845,000
ST Investments
$1,704,520,000
EBIT TTM
$-479,546,000
Pretax Income TTM
$-562,001,000
Interest Exp TTM
$82,455,000
Analysts
21
Yahoo Snapshot (yfinance, live)
Total Revenue
$874,092,992
EBITDA
$-579,484,992
Free Cash Flow
$-346,764,640
Enterprise Value
$9,095,519,232
Total Cash
$2,102,353,024
Total Debt
$2,189,019,904
Shares Out
166,184,322
Trailing EPS
$-3.48
Book Value
$2.65
ROE
-105.5%
ROA
-12.4%
Div Yield
—
Annual Trend (SEC EDGAR, last 4y)
Revenues vs Net Income (last 4y)
| FY end | Revenues | Op income | Net income | Assets | Liabilities | Equity | Op cash flow |
|---|---|---|---|---|---|---|---|
| Dec 2025 | 943,711,000 | -381,717,000 | -381,387,000 | 3,523,836,000 | 3,034,747,000 | 489,089,000 | -268,583,000 |
| Dec 2024 | 705,138,000 | -475,107,000 | -453,897,000 | 3,003,675,000 | 2,415,324,000 | 588,351,000 | -500,947,000 |
| Dec 2023 | 787,647,000 | -353,730,000 | -366,286,000 | 2,990,072,000 | 2,603,386,000 | 386,686,000 | -307,513,000 |
| Dec 2022 | 587,367,000 | -410,191,000 | -269,722,000 | 2,533,876,000 | 1,960,989,000 | 572,887,000 | -274,370,000 |
TTM Snapshot
Revenues TTM
$569,400,000
NetIncome TTM
$-481,820,000
OpCashFlow TTM
$0
Assets (Latest)
$3,523,836,000
Forward EPS
$-1.11
Max Pain — expiry 2026-10-16 (volume-derived — Yahoo OI feed degraded)
max pain strike: $80.00 · spot: $44.00 · call volume: 238 · put volume: 2,801
Expected Move to 2026-10-16:
±$2.74
(6.23%) —
implied range
$41.26 –
$46.74
· ATM straddle on $45.00 strike
Peers — same industry
| Ticker | Name | Market Cap | Last | Daily % |
|---|---|---|---|---|
| AMRX | Amneal Pharmaceuticals, Inc. | $6.99B | $20.07 | — |
| ALKS | Alkermes plc. | $6.80B | $40.54 | — |
| SYRE | Spyre Therapeutics, Inc. | $7.93B | $89.93 | — |
| PRAX | Praxis Precision Medicines, Inc. | $8.01B | $286.91 | — |
| BLTE | BELITE BIO, INC | $6.56B | $162.98 | — |
News headlines (Yahoo Finance, 1h cache)
Ionis Delivers Positive Late-Stage Results for Two Partnered Drugs
2026-09-23 16:13 · Yahoo
Ionis announces positive topline results from Phase 3 FUSION study of ulefnersen marking significant milestone in advancing first potential disease modifying treatment for FUS-ALS
2026-09-22 12:00 · Yahoo
Beyond Meta, Cathie Wood’s ARKG Loads Up On These 4 Biotech Names
2026-09-22 11:10 · Yahoo
Investors Dumped Ionis Pharmaceuticals Stock -- But Wall Street Hasn't Budged From Its Bullish Outlook
2026-09-20 13:50 · Yahoo
Ionis Pharmaceuticals Eyes TRYNGOLZA Growth as Pipeline Faces Cardio Setbacks
2026-09-19 09:02 · Yahoo
Failure of Novartis’ Pelacarsen Could Reshape the Lp(a) Race for CRISPR and Ionis
2026-09-24 16:42 · Yahoo
Ionis announces positive interim data from partner Roche’s Phase 3 IMAgINATION study in IgA nephropathy (IgAN)
2026-09-23 05:00 · Yahoo
Novartis Suffers Another Setback After Two High-Profile Surprises Hammered Shares
2026-09-16 20:03 · Yahoo
Cathie Wood Makes $64 Million Bet on Two Stocks
2026-09-28 19:11 · Yahoo
4 RNA Therapeutics Stocks Leading the Next Wave of Innovation
2026-09-28 13:57 · Yahoo
Recent Insider Activity
No insider activity indexed for this ticker.