PTGX — Protagonist Therapeutics, Inc

Nasdaq · Health Care · Pharmaceuticals · CIK 1377121 ·
Last close
$99.98
Market Cap
$6.43B
52W High
$107.84
52W Low
$87.15
ADV30
582,541
Next earnings
2026-05-05
Protagonist Therapeutics, Inc. operates as a discovery and development company in the United States. It develops Icotyde, a first-in-class investigational targeted oral peptide for the treatment of adults and pediatric patients 12 years of age and older with moderate-to-severe plaque psoriasis; and Rusfertide, a first-in-class investigational injectable mimetic of the natural hormone hepcidin in Phase 3 development for the treatment of the rare blood disorder polycythemia vera. The company is also developing PN-881, a potential best-in-class oral peptide IL-17 antagonist, for the treatment of immune-mediated skin diseases in Phase 1 clinical trials; PN-477 and PN-458, which are development candidates for the treatment of obesity; PN-8047, an orally administered hepcidin functional mimetic small molecule; L-4R alpha antagonist for the treatment of atopic dermatitis and moderate-to-severe asthma; and amylinR-based oral and subcutaneous mono- and poly-agonists for the treatment of obesity. Protagonist Therapeutics, Inc. was incorporated in 2006 and is headquartered in Newark, California.

Quarterly Fundamentals

Revenues vs Net Income (last 4 Q)

Assets vs Liabilities (last 4 Q)

PeriodRevenuesGrossProfit OpIncomeNetIncomeAssets CashLiabilities
Mar 2026 56,368,000 -3,648,000 3,783,000 697,459,000 193,712,000 41,986,000
Dec 2025 7,437,000 -50,355,000 -44,384,000 668,188,000 128,390,000 53,481,000
Sep 2025 4,712,000 -46,421,000 -39,339,000 701,688,000 113,713,000 56,251,000
Jun 2025 5,546,000 -42,041,000 -34,771,000 718,006,000 168,543,000 49,988,000

Cashflow TTM (yfinance, fills SEC gap)

Operating CF
$-116,635,000
Investing CF
$135,962,000
Financing CF
$34,795,000
CapEx
$-1,260,000
Dividends Paid
Buybacks
EPS Diluted TTM
$-1.81
As of
2026-05-10

Balance + Analyst (yfinance extras)

Retained Earnings
$-466,888,000
Inventory
Receivables
$57,122,000
ST Investments
$354,074,000
EBIT TTM
$-142,465,000
Pretax Income TTM
$-115,375,000
Interest Exp TTM
Analysts
12

Yahoo Snapshot (yfinance, live)

Total Revenue
$74,063,000
EBITDA
$-141,016,992
Free Cash Flow
$-77,664,624
Enterprise Value
$5,841,035,264
Total Cash
$547,785,984
Total Debt
$9,776,000
Shares Out
64,311,373
Trailing EPS
$-1.82
Book Value
$10.21
ROE
-17.1%
ROA
-12.4%
Div Yield

Annual Trend (SEC EDGAR, last 4y)

Revenues vs Net Income (last 4y)

FY endRevenuesOpIncome NetIncomeAssetsLiabilities EquityOCF
Dec 2025 46,016,000 -158,127,000 -130,149,000 668,188,000 53,481,000 57,671,000
Dec 2024 434,433,000 252,843,000 275,188,000 744,725,000 69,430,000 184,152,000
Dec 2023 60,000,000 -93,652,000 -78,955,000 357,951,000 21,274,000 -70,236,000
Dec 2022 26,581,000 -131,373,000 -127,393,000 247,928,000 32,320,000 -108,137,000

TTM Snapshot

Revenues TTM
$0
NetIncome TTM
$-7,084,000
OpCashFlow TTM
$0
Assets (Latest)
$93,990,000
Forward EPS
$-0.68

Peers — same industry

TickerNameMarket CapLastDaily %
SYRE Spyre Therapeutics, Inc. $6.40B $73.65
CORT CORCEPT THERAPEUTICS INC $6.48B $60.36
ALKS Alkermes plc. $6.23B $37.35
RYTM RHYTHM PHARMACEUTICALS, INC. $6.16B $89.82
CNTA Centessa Pharmaceuticals plc $6.16B $39.78

News headlines (Yahoo Finance, 1h cache)

Hedge Fund Wagers $36 Million on Biotech Denali After First FDA Approval
2026-05-18 18:43 · Yahoo
Hedge Fund Drops $40 Million on Gene-Editing Biotech Beam. Is It a Buy?
2026-05-18 18:25 · Yahoo
Hedge Fund Drops $37 Million on Rare Disease Biotech Crinetics. Is It a Buy?
2026-05-18 18:10 · Yahoo
Analyst Forecasts For Protagonist Therapeutics, Inc. (NASDAQ:PTGX) Are Surging Higher
2026-05-11 13:05 · Yahoo
Protagonist Therapeutics, Inc. Surprised Analysts With A Profit, And Analysts Boosted Their EPS Forecasts
2026-05-08 12:25 · Yahoo
Is It Too Late To Consider Protagonist Therapeutics (PTGX) After Its 141% One Year Surge?
2026-05-07 01:14 · Yahoo
Protagonist Reports First Quarter 2026 Financial Results and Provides Corporate Update
2026-05-05 20:05 · Yahoo
Protagonist Therapeutics Inc. (PTGX): Billionaire Tom Steyer Likes Upside Potential of This Stock
2026-05-02 14:49 · Yahoo
Protagonist Exercises Rusfertide U.S. Opt-Out Right Under Takeda Collaboration
2026-04-28 13:05 · Yahoo
Protagonist Therapeutics Inc. (PTGX): Billionaire Joe Edelman Likes This Stock
2026-04-27 14:07 · Yahoo

Recent Insider Activity

No insider activity indexed for this ticker.