PTGX — Protagonist Therapeutics, Inc

Nasdaq · Health Care · Pharmaceuticals · CIK 1377121 ·
Last close
$131.42
Market Cap
$8.45B
52W High
$141.10
52W Low
$92.75
ADV30
868,613
Next earnings
2026-05-05
Protagonist Therapeutics, Inc. operates as a discovery and development company in the United States. It develops Icotyde, a first-in-class investigational targeted oral peptide for the treatment of adults and pediatric patients 12 years of age and older with moderate-to-severe plaque psoriasis; and Rusfertide, a first-in-class investigational injectable mimetic of the natural hormone hepcidin in Phase 3 development for the treatment of the rare blood disorder polycythemia vera. The company is also developing PN-881, a potential best-in-class oral peptide IL-17 antagonist, for the treatment of immune-mediated skin diseases in Phase 1 clinical trials; PN-477 and PN-458, which are development candidates for the treatment of obesity; PN-8047, an orally administered hepcidin functional mimetic small molecule; L-4R alpha antagonist for the treatment of atopic dermatitis and moderate-to-severe asthma; and amylinR-based oral and subcutaneous mono- and poly-agonists for the treatment of obesity. Protagonist Therapeutics, Inc. was incorporated in 2006 and is headquartered in Newark, California.

Quarterly Fundamentals

Revenues vs Net Income (last 4 Q)

Assets vs Liabilities (last 4 Q)

PeriodRevenuesGrossProfit OpIncomeNetIncomeAssets CashLiabilities
Mar 2026 56,368,000 -3,648,000 3,783,000 697,459,000 193,712,000 41,986,000
Dec 2025 7,437,000 -50,355,000 -44,384,000 668,188,000 128,390,000 53,481,000
Sep 2025 4,712,000 -46,421,000 -39,339,000 701,688,000 113,713,000 56,251,000
Jun 2025 5,546,000 -42,041,000 -34,771,000 718,006,000 168,543,000 49,988,000

Cashflow TTM (yfinance, fills SEC gap)

Operating CF
$-116,635,000
Investing CF
$135,962,000
Financing CF
$34,795,000
CapEx
$-1,260,000
Dividends Paid
Buybacks
EPS Diluted TTM
$-1.81
As of
2026-05-10

Balance + Analyst (yfinance extras)

Retained Earnings
$-466,888,000
Inventory
Receivables
$57,122,000
ST Investments
$354,074,000
EBIT TTM
$-142,465,000
Pretax Income TTM
$-115,375,000
Interest Exp TTM
Analysts
12

Yahoo Snapshot (yfinance, live)

Total Revenue
$74,063,000
EBITDA
$-141,016,992
Free Cash Flow
$-77,664,624
Enterprise Value
$8,313,807,360
Total Cash
$547,785,984
Total Debt
$9,776,000
Shares Out
64,311,373
Trailing EPS
$-1.82
Book Value
$10.21
ROE
-17.1%
ROA
-12.4%
Div Yield

Annual Trend (SEC EDGAR, last 4y)

Revenues vs Net Income (last 4y)

FY endRevenuesOpIncome NetIncomeAssetsLiabilities EquityOCF
Dec 2025 46,016,000 -158,127,000 -130,149,000 668,188,000 53,481,000 57,671,000
Dec 2024 434,433,000 252,843,000 275,188,000 744,725,000 69,430,000 184,152,000
Dec 2023 60,000,000 -93,652,000 -78,955,000 357,951,000 21,274,000 -70,236,000
Dec 2022 26,581,000 -131,373,000 -127,393,000 247,928,000 32,320,000 -108,137,000

TTM Snapshot

Revenues TTM
$0
NetIncome TTM
$-7,084,000
OpCashFlow TTM
$0
Assets (Latest)
$93,990,000
Forward EPS
$-0.63

Peers — same industry

TickerNameMarket CapLastDaily %
SYRE Spyre Therapeutics, Inc. $8.49B $97.74
ALKS Alkermes plc. $8.66B $51.94
TGTX TG THERAPEUTICS, INC. $8.74B $57.12
CRNX Crinetics Pharmaceuticals, Inc. $8.85B $83.58
PRAX Praxis Precision Medicines, Inc. $9.06B $324.99

News headlines (Yahoo Finance, 1h cache)

Protagonist Therapeutics (PTGX) Stock Still Looks Stretched After FDA Priority Review
2026-07-09 16:10 · Yahoo
Protagonist Therapeutics (PTGX) After Icotyde Launch And Rusfertide Review Looks Undervalued
2026-07-09 14:14 · Yahoo
New Strong Buy Stocks for July 9th
2026-07-09 08:53 · Yahoo
Protagonist Therapeutics (PTGX) Is Up 12.5% After Rusfertide Priority Review Focus - Has The Bull Case Changed?
2026-07-08 16:18 · Yahoo
Protagonist Therapeutics (PTGX) Surges 7.1%: Is This an Indication of Further Gains?
2026-07-08 14:30 · Yahoo
Strength Seen in Agios Pharmaceuticals (AGIO): Can Its 17.7% Jump Turn into More Strength?
2026-07-08 14:29 · Yahoo
Why Wall Street’s Wrong for Loving Protagonist Therapeutics Stock
2026-07-02 14:15 · Yahoo
Protagonist Therapeutics Reports Granting of Inducement Awards
2026-07-01 20:05 · Yahoo
Protagonist Therapeutics to Present Phase 3 VERIFY and Long-Term Rusfertide Data at the 2026 European Hematology Association Congress
2026-06-01 11:05 · Yahoo
Why This Fund Made a $189 Million Bet on Erasca as Shares Skyrocket 800%
2026-05-30 00:47 · Yahoo

Recent Insider Activity

No insider activity indexed for this ticker.