SEPN — Septerna, Inc.

Nasdaq · Health Care · Pharmaceuticals · CIK 1984086 ·
Last close
$30.65
Market Cap
$1.38B
52W High
$30.78
52W Low
$22.78
ADV30
355,940
Next earnings
Septerna, Inc., a clinical-stage biotechnology company, discovers and develops G protein-coupled receptor (GPCR) oral small molecule products for the treatment of endocrinology, immunology and inflammation, and metabolic diseases. It develops PTH1R Program, oral small molecule Parathyroid Hormone 1 Receptor agonists for the treatment of hypoparathyroidism; SEP-631, an oral small molecule MRGPRX2 negative allosteric modulator (NAM) for chronic spontaneous urticaria and other mast cell diseases; and TSHR Program, an oral small molecule TSHR NAM for graves' disease and thyroid eye disease. In addition, it focuses on other therapeutic areas, including neurology, women's health, cardiovascular disease, and respiratory disease. It has global collaboration and license agreement with Novo Nordisk to discover, develop and commercialize multiple potential oral small molecule therapies for metabolic-related diseases based on certain specified molecular targets. The company was formerly known as GPCR NewCo, Inc. and changed its name to Septerna Inc. in June 2021. Septerna, Inc. was incorporated in 2019 and is headquartered in South San Francisco, California.

Quarterly Fundamentals

Revenues vs Net Income (last 4 Q)

Assets vs Liabilities (last 4 Q)

PeriodRevenuesGrossProfit OpIncomeNetIncomeAssets CashLiabilities
Mar 2026 26,523,000 -13,300,000 -8,637,000 569,688,000 71,605,000 191,230,000
Dec 2025 24,118,000 -16,023,000 -10,738,000 596,187,000 120,722,000 214,261,000
Sep 2025 21,495,000 -9,886,000 8,173,000 606,653,000 319,989,000 217,922,000
Jun 2025 119,000 -28,978,000 -24,838,000 415,231,000 189,311,000 37,674,000

Cashflow TTM (yfinance, fills SEC gap)

Operating CF
$110,189,000
Investing CF
$-229,352,000
Financing CF
$1,689,000
CapEx
$-518,000
Dividends Paid
Buybacks
$0
EPS Diluted TTM
$-1.11
As of
2026-05-10

Balance + Analyst (yfinance extras)

Retained Earnings
$-167,253,000
Inventory
Receivables
$13,740,000
ST Investments
$270,367,000
EBIT TTM
$-80,797,000
Pretax Income TTM
$-48,867,000
Interest Exp TTM
Analysts
8

Yahoo Snapshot (yfinance, live)

Total Revenue
$72,255,000
EBITDA
$-66,559,000
Free Cash Flow
$24,014,124
Enterprise Value
$954,031,104
Total Cash
$347,400,992
Total Debt
$23,090,000
Shares Out
45,075,533
Trailing EPS
$-0.80
Book Value
$8.52
ROE
-9.3%
ROA
-8.5%
Div Yield

Annual Trend (SEC EDGAR, last 4y)

Revenues vs Net Income (last 4y)

FY endRevenuesOpIncome NetIncomeAssetsLiabilities EquityOCF
Dec 2025 45,951,000 -80,797,000 -48,879,000 596,187,000 214,261,000 110,189,000
Dec 2024 1,075,000 -80,823,000 -71,798,000 456,554,000 36,507,000 -67,470,000
Dec 2023 151,000 -45,550,000 4,180,000 130,867,000 169,241,000 -38,723,000
Dec 2022 0 -27,967,000 -27,676,000 36,119,000 80,320,000 -23,303,000

TTM Snapshot

Revenues TTM
NetIncome TTM
OpCashFlow TTM
Assets (Latest)
Forward EPS
$-2.66

Peers — same industry

TickerNameMarket CapLastDaily %
MLTX MoonLake Immunotherapeutics $1.34B $18.23
KALV KalVista Pharmaceuticals, Inc. $1.43B $26.81
URGN UroGen Pharma Ltd. $1.44B $29.46
BCAX Bicara Therapeutics Inc. $1.44B $21.98
AVBP ArriVent BioPharma, Inc. $1.30B $27.94

News headlines (Yahoo Finance, 1h cache)

Party Time: Brokers Just Made Major Increases To Their Septerna, Inc. (NASDAQ:SEPN) Earnings Forecasts
2026-05-17 14:47 · Yahoo
Earnings Update: Septerna, Inc. (NASDAQ:SEPN) Just Reported And Analysts Are Boosting Their Estimates
2026-05-15 14:08 · Yahoo
Septerna, Inc. (SEPN) Reports Q1 Loss, Tops Revenue Estimates
2026-05-11 21:25 · Yahoo
Septerna Highlights Business Progress and Reports First Quarter 2026 Financial Results
2026-05-11 20:01 · Yahoo
Liquidia Corporation (LQDA) Surpasses Q1 Earnings and Revenue Estimates
2026-05-11 11:45 · Yahoo
How Analyst Upgrade and Conference Spotlight Will Impact Septerna (SEPN) Investors
2026-05-08 13:19 · Yahoo
Zymeworks Inc. (ZYME) Reports Q1 Loss, Misses Revenue Estimates
2026-05-07 23:05 · Yahoo
Septerna to Present at Bank of America Securities Health Care Conference
2026-05-05 12:00 · Yahoo
Axsome Therapeutics (AXSM) Reports Q1 Loss, Beats Revenue Estimates
2026-05-04 12:15 · Yahoo
Septerna Announces Initiation of Phase 1 Clinical Trial of SEP-479, an Oral Small Molecule PTH1R Agonist for the Treatment of Hypoparathyroidism
2026-04-13 12:00 · Yahoo

Recent Insider Activity

No insider activity indexed for this ticker.