SPRO — Spero Therapeutics, Inc.

Nasdaq · Health Care · Pharmaceuticals · CIK 1701108 ·
Last close
$2.10
Market Cap
$121.59M
52W High
$3.08
52W Low
$1.95
ADV30
1,417,904
Next earnings
2026-08-11
Spero Therapeutics, Inc., a clinical-stage biopharmaceutical company, focuses on identifying and developing novel treatments for multi-drug resistant (MDR) bacterial infections and rare diseases in the United States. The company's product candidates include Tebipenem HBr (tebipenem pivoxil hydrobromide), an oral carbapenem-class antibiotic to treat complicated urinary tract infections, including pyelonephritis for adult patients, which has completed second Phase 3 trial. It has license agreement with Meiji Seika Pharma Co., Ltd. to develop, manufacture, and commercialize tebipenem pivoxil and tebipenem HBr; and Everest Medicines to develop, manufacture, and commercialize SPR206 in Greater China, South Korea, and Southeast Asian countries. Spero Therapeutics, Inc. was incorporated in 2013 and is headquartered in Cambridge, Massachusetts.

Quarterly Fundamentals

Revenues vs Net Income (last 4 Q)

Assets vs Liabilities (last 4 Q)

PeriodRevenuesGrossProfit OpIncomeNetIncomeAssets CashLiabilities
Mar 2026 258,000 -7,538,000 -7,203,000 59,021,000 56,129,000 6,087,000
Dec 2025 39,658,000 31,405,000 31,520,000 68,919,000 40,265,000 9,898,000
Sep 2025 3,048,000 -7,329,000 -7,382,000 54,170,000 48,616,000 27,676,000
Jun 2025 11,802,000 -2,361,000 -1,700,000 62,119,000 31,194,000 29,291,000

Cashflow TTM (yfinance, fills SEC gap)

Operating CF
$7,242,000
Investing CF
Financing CF
$0
CapEx
Dividends Paid
Buybacks
EPS Diluted TTM
$0.24
As of
2026-06-07

Balance + Analyst (yfinance extras)

Retained Earnings
$-458,269,000
Inventory
Receivables
$44,000
ST Investments
EBIT TTM
$14,177,000
Pretax Income TTM
$15,496,000
Interest Exp TTM
Analysts
1

Yahoo Snapshot (yfinance, live)

Total Revenue
$61,186,000
EBITDA
Free Cash Flow
$13,249,625
Enterprise Value
$69,096,168
Total Cash
$56,129,000
Total Debt
$2,474,000
Shares Out
57,901,493
Trailing EPS
$0.27
Book Value
$0.91
ROE
35.1%
ROA
13.0%
Div Yield

Annual Trend (SEC EDGAR, last 4y)

Revenues vs Net Income (last 4y)

FY endRevenuesOpIncome NetIncomeAssetsLiabilities EquityOCF
Dec 2025 59,619,000 7,159,000 8,572,000 68,919,000 9,898,000 -12,624,000
Dec 2024 27,396,000 -72,484,000 -68,566,000 110,543,000 64,420,000 -23,444,000
Dec 2023 96,735,000 26,787,000 22,806,000 182,390,000 75,496,000 -32,995,000
Dec 2022 48,579,000 -30,567,000 -46,415,000 124,802,000 48,868,000 -7,731,000

TTM Snapshot

Revenues TTM
NetIncome TTM
OpCashFlow TTM
Assets (Latest)
Forward EPS
$-1.11

Max Pain — expiry 2026-07-17

max pain strike: $2.50 · spot: $2.10 · call oi: 8,817 · put oi: 1,262
Expected Move to 2026-07-17: ±$0.45 (21.43%) — implied range $1.65$2.55 · ATM straddle on $2.50 strike

Peers — same industry

TickerNameMarket CapLastDaily %
COYA Coya Therapeutics, Inc. $123.38M $5.26
ALDX Aldeyra Therapeutics, Inc. $124.86M $2.07
NTHI NEONC TECHNOLOGIES HOLDINGS, INC. $116.43M $4.49
BGM BGM Group Ltd. $127.51M $0.34
PMN ProMIS Neurosciences Inc. $127.79M $14.25

News headlines (Yahoo Finance, 1h cache)

Avacta Appoints Healthcare Executive Patrick Vink as Deputy Chairman of the Board of Directors
2026-07-08 06:00 · Yahoo
Kailera Therapeutics Appoints Kathleen Tregoning as Chief Corporate Affairs Officer
2026-06-29 11:30 · Yahoo
GSK (LSE:GSK) Wins FDA Approval For Utebzi As Momelotinib Gains Orphan Tag
2026-06-26 14:07 · Yahoo
Is GSK plc (GSK) Expanding Its Anti-Infectives Leadership With New FDA-Approved Therapy?
2026-06-24 13:27 · Yahoo
GSK, Spero Win FDA Nod For First-Ever Oral Carbapenem Antibiotic For Complicated UTIs
2026-06-21 14:31 · Yahoo
Spero Shares Jump After FDA Clears First Oral Carbapenem Antibiotic for U.S. Market (SPRO)
2026-06-18 13:52 · Yahoo
Utebzi (tebipenem pivoxil) approved in the US for adults with complicated urinary tract infections (cUTIs)
2026-06-17 20:21 · Yahoo
Promising Penny Stocks To Consider In May 2026
2026-05-15 12:05 · Yahoo
Spero Therapeutics Announces First Quarter 2026 Operating Results and Provides Business Update
2026-05-13 20:05 · Yahoo
Inventiva Builds Up Leadership Team Ahead of Potential Commercialization
2026-04-22 22:03 · Yahoo

Recent Insider Activity

No insider activity indexed for this ticker.