SPRO — Spero Therapeutics, Inc.

Nasdaq · Health Care · Pharmaceuticals · CIK 1701108 ·
Last close
$1.22
Market Cap
$70.76M
52W High
$3.08
52W Low
$1.08
ADV30
1,783,932
Next earnings
2026-11-12
Spero Therapeutics, Inc., a clinical-stage biopharmaceutical company, focuses on identifying and developing novel treatments for multi-drug resistant (MDR) bacterial infections and rare diseases in the United States. The company's product candidates include Tebipenem HBr (tebipenem pivoxil hydrobromide), an oral carbapenem-class antibiotic to treat complicated urinary tract infections, including pyelonephritis for adult patients, which has completed second Phase 3 trial. It has license agreement with Meiji Seika Pharma Co., Ltd. to develop, manufacture, and commercialize tebipenem pivoxil and tebipenem HBr; and Everest Medicines to develop, manufacture, and commercialize SPR206 in Greater China, South Korea, and Southeast Asian countries. Spero Therapeutics, Inc. was incorporated in 2013 and is headquartered in Cambridge, Massachusetts.

Quarterly Fundamentals

Revenues vs Net Income (last 4 Q)

Assets vs Liabilities (last 4 Q)

PeriodRevenuesGrossProfit OpIncomeNetIncomeAssets CashLiabilities
Mar 2026 258,000 -7,538,000 -7,203,000 59,021,000 56,129,000 6,087,000
Dec 2025 39,658,000 31,405,000 31,520,000 68,919,000 40,265,000 9,898,000
Sep 2025 3,048,000 -7,329,000 -7,382,000 54,170,000 48,616,000 27,676,000
Jun 2025 11,802,000 -2,361,000 -1,700,000 62,119,000 31,194,000 29,291,000

Cashflow TTM (yfinance, fills SEC gap)

Operating CF
$7,242,000
Investing CF
Financing CF
$0
CapEx
Dividends Paid
Buybacks
EPS Diluted TTM
$0.24
As of
2026-08-16

Balance + Analyst (yfinance extras)

Retained Earnings
$-458,269,000
Inventory
Receivables
$44,000
ST Investments
EBIT TTM
$14,177,000
Pretax Income TTM
$15,496,000
Interest Exp TTM
Analysts
1

Yahoo Snapshot (yfinance, live)

Total Revenue
$46,997,000
EBITDA
Free Cash Flow
$28,848,500
Enterprise Value
$22,024,314
Total Cash
$50,774,000
Total Debt
$2,043,000
Shares Out
58,234,827
Trailing EPS
$0.14
Book Value
$0.76
ROE
19.2%
ROA
7.2%
Div Yield

Annual Trend (SEC EDGAR, last 4y)

Revenues vs Net Income (last 4y)

FY endRevenuesOpIncome NetIncomeAssetsLiabilities EquityOCF
Dec 2025 59,619,000 7,159,000 8,572,000 68,919,000 9,898,000 -12,624,000
Dec 2024 27,396,000 -72,484,000 -68,566,000 110,543,000 64,420,000 -23,444,000
Dec 2023 96,735,000 26,787,000 22,806,000 182,390,000 75,496,000 -32,995,000
Dec 2022 48,579,000 -30,567,000 -46,415,000 124,802,000 48,868,000 -7,731,000

TTM Snapshot

Revenues TTM
NetIncome TTM
OpCashFlow TTM
Assets (Latest)
Forward EPS
$-1.11

Max Pain — expiry 2026-10-16 (volume-derived — Yahoo OI feed degraded)

max pain strike: $1.00 · spot: $1.23 · call volume: 105 · put volume: 10

Peers — same industry

TickerNameMarket CapLastDaily %
PLRX PLIANT THERAPEUTICS, INC. $70.59M $1.14
IBIO iBio, Inc. $70.54M $1.42
XBIT XBiotech Inc. $70.43M $2.31
PMVP PMV Pharmaceuticals, Inc. $69.76M $1.30
OSTX OS Therapies Inc $72.03M $1.55

News headlines (Yahoo Finance, 1h cache)

Spero Therapeutics (SPRO) Q2 2026 Earnings Call Transcript
2026-08-19 21:28 · Yahoo
Spero Therapeutics Announces Second Quarter 2026 Operating Results and Provides Business Update
2026-08-12 20:01 · Yahoo
Spero Therapeutics Announces Inducement Grant Under Nasdaq Listing Rule 5635(c)(4)
2026-08-05 20:05 · Yahoo
Spero Therapeutics to Report Second Quarter 2026 Financial Results and Provide Business Update on August 12, 2026
2026-08-04 20:01 · Yahoo
Spero Therapeutics Appoints Debra Jeske Zack, M.D., Ph.D., as Chief Medical Officer
2026-07-27 12:00 · Yahoo
Innovent licenses IBI355 rights to Spero for up to $1.1bn
2026-07-15 10:01 · Yahoo
J&J dips despite upbeat outlook; AstraZeneca, Spero cut China deals
2026-07-15 09:18 · Yahoo
Spero Therapeutics Announces $105 Million Non-Recourse Non-Dilutive Financing Backed by a Portion of Utebzi Milestones & Royalties
2026-07-14 10:02 · Yahoo
Innovent Biologics and Spero Therapeutics Announce Exclusive License for IBI355 (SP001), a Phase 2-Ready Third-Generation Anti-CD40L Antibody
2026-07-14 10:00 · Yahoo
Avacta Appoints Healthcare Executive Patrick Vink as Deputy Chairman of the Board of Directors
2026-07-08 06:00 · Yahoo

Recent Insider Activity

No insider activity indexed for this ticker.