SPRB — SPRUCE BIOSCIENCES, INC.

Nasdaq · Health Care · Pharmaceuticals · CIK 1683553 ·
Last close
$51.81
Market Cap
$142.60M
52W High
$80.00
52W Low
$48.25
ADV30
78,066
Next earnings
Spruce Biosciences, Inc. is a biopharmaceutical company focused on developing and commercializing novel therapies for neurological disorders. The company develops TA-ERT, a fusion protein comprised of recombinant human alpha-N-acetylglucosaminidase, which is an enzyme replacement therapy for patients with Sanfilippo Syndrome Type B. It also develops Tildacerfont for treating a highly debilitating mental disorder characterized by depressed mood with cognitive-affective and somatic changes, including anhedonia, weight alterations, and altered sleeping patterns. In addition, the company develops SPR202 for the treatment of Congenital Adrenal Hyperplasia (CAH), a chronic and potentially life-threatening rare disease with no cure. The company has a license agreement with Eli Lilly and Company to research, develop, and commercialize various pharmaceutical compounds. It also has a collaboration and license agreement with Kaken Pharmaceutical Co. Ltd. to develop, manufacture, and commercialize Tildacerfont for the treatment of CAH in Japan. Spruce Biosciences, Inc. was incorporated in 2014 and is headquartered in South San Francisco, California.

Quarterly Fundamentals

Revenues vs Net Income (last 4 Q)

Assets vs Liabilities (last 4 Q)

PeriodRevenuesGrossProfit OpIncomeNetIncomeAssets CashLiabilities
Mar 2026 0 -11,987,000 -12,266,000 56,166,000 54,080,000 21,518,000
Dec 2025 0 -11,100,000 -14,646,000 53,021,000 48,906,000 10,505,000
Sep 2025 0 -8,229,000 -8,212,000 15,313,000 10,669,000 9,927,000
Jun 2025 0 -2,692,000 -2,067,000 21,820,000 16,387,000 8,640,000

Cashflow TTM (yfinance, fills SEC gap)

Operating CF
$-33,327,000
Investing CF
$0
Financing CF
$43,481,000
CapEx
Dividends Paid
Buybacks
EPS Diluted TTM
$-57.82
As of
2026-05-10

Balance + Analyst (yfinance extras)

Retained Earnings
$-289,234,000
Inventory
Receivables
ST Investments
EBIT TTM
$-38,876,000
Pretax Income TTM
$-38,966,000
Interest Exp TTM
$90,000
Analysts
5

Annual Trend (SEC EDGAR, last 4y)

Revenues vs Net Income (last 4y)

FY endRevenuesOpIncome NetIncomeAssetsLiabilities EquityOCF
Dec 2025 0 -36,513,000 -38,966,000 53,021,000 10,505,000 -33,327,000
Dec 2024 4,911,000 -56,151,000 -53,036,000 45,209,000 16,388,000 -55,964,000
Dec 2023 10,089,000 -51,993,000 -47,919,000 103,946,000 27,437,000 -33,275,000
Dec 2022 0 -47,283,000 -46,180,000 85,648,000 17,162,000 -41,683,000

TTM Snapshot

Revenues TTM
NetIncome TTM
OpCashFlow TTM
Assets (Latest)
Forward EPS
$1.85

Peers — same industry

TickerNameMarket CapLastDaily %
KZIA KAZIA THERAPEUTICS LTD $142.95M $12.51
MSLE Satellos Bioscience Inc. $141.76M $6.80
CRBP Corbus Pharmaceuticals Holdings, Inc. $146.55M $7.91
EQ Equillium, Inc. $146.69M $2.32
CNTB Connect Biopharma Holdings Ltd $135.65M $2.40

News headlines (Yahoo Finance, 1h cache)

Spruce Biosciences Reports First Quarter 2026 Financial Results and Provides Corporate Updates
2026-05-13 12:00 · Yahoo
Spruce Biosciences Further Strengthens its Commercial Leadership Team with the Appointments of Brian Walls as Vice President, Market Access and Darren Johnson as Vice President, Commercial Operations
2026-05-04 12:00 · Yahoo
Spruce Biosciences Announces Pricing of Public Offering of Common Stock and Pre-Funded Warrants
2026-04-21 03:45 · Yahoo
Spruce Biosciences Announces Proposed Public Offering of Common Stock and Pre-Funded Warrants
2026-04-20 20:01 · Yahoo
Wall Street Analysts Believe Spruce Biosciences (SPRB) Could Rally 181.21%: Here's is How to Trade
2026-04-03 13:55 · Yahoo
Does Spruce Biosciences (SPRB) Have the Potential to Rally 208.32% as Wall Street Analysts Expect?
2026-03-18 13:55 · Yahoo
Spruce Biosciences (SPRB) Appoints Dale Hooks as CCO and Reports Narrowed $39M 2025 Net Loss
2026-03-17 23:59 · Yahoo
Spruce Biosciences Reports Full Year 2025 Financial Results and Provides Corporate Updates
2026-03-09 11:05 · Yahoo
Spruce Biosciences Appoints Dale Hooks, an Accomplished Rare Disease Commercial Leader, as Chief Commercial Officer
2026-03-09 11:00 · Yahoo
Spruce Biosciences (SPRB) Gains FDA Support for Accelerated Approval Pathway
2026-03-04 05:11 · Yahoo

Recent Insider Activity

No insider activity indexed for this ticker.