TLPH — TALPHERA, INC.

Nasdaq · Health Care · Pharmaceuticals · CIK 1427925 ·
Last close
$0.80
Market Cap
$41.52M
52W High
$0.99
52W Low
$0.69
ADV30
141,210
Next earnings
2026-08-13
Talphera, Inc., a specialty pharmaceutical company, focuses on the development and commercialization of therapies for use in medically supervised settings. The company's lead product candidate, Niyad, is a lyophilized formulation of nafamostat that acts as a regional anticoagulant for infusion into the extracorporeal circuit. It is also developing LTX-608, a lyophilized vial containing nafamostat for IV infusion for disseminated intravascular coagulation, acute respiratory distress syndrome, acute pancreatitis, and an anti-viral treatment; Fedsyra, an ephedrine pre-filled syringe for injection; and a phenylephrine pre-filled syringe for injection. The company was formerly known as AcelRx Pharmaceuticals, Inc. and changed its name to Talphera, Inc. in January 2024. The company was incorporated in 2005 and is headquartered in San Mateo, California.

Quarterly Fundamentals

Revenues vs Net Income (last 4 Q)

Assets vs Liabilities (last 4 Q)

PeriodRevenuesGrossProfit OpIncomeNetIncomeAssets CashLiabilities
Mar 2026 0 -3,948,000 -2,556,000 30,155,000 3,823,000 11,677,000
Dec 2025 0 -3,453,000 -3,772,000 29,719,000 5,894,000 12,684,000
Sep 2025 1,000 -3,422,000 -4,436,000 30,742,000 3,457,000 11,565,000
Jun 2025 0 -3,693,000 -3,489,000 16,515,000 6,791,000 9,888,000

Cashflow TTM (yfinance, fills SEC gap)

Operating CF
$-11,364,000
Investing CF
$-14,345,000
Financing CF
$22,740,000
CapEx
Dividends Paid
Buybacks
EPS Diluted TTM
$-0.37
As of
2026-05-10

Balance + Analyst (yfinance extras)

Retained Earnings
$-471,520,000
Inventory
Receivables
ST Investments
$14,487,000
EBIT TTM
$-14,363,000
Pretax Income TTM
$-14,363,000
Interest Exp TTM
$0
Analysts
2

Yahoo Snapshot (yfinance, live)

Total Revenue
$1,000
EBITDA
Free Cash Flow
$-5,777,500
Enterprise Value
$27,694,404
Total Cash
$21,108,000
Total Debt
$6,499,000
Shares Out
51,899,648
Trailing EPS
$-0.28
Book Value
$0.34
ROE
-118.4%
ROA
-40.2%
Div Yield

Annual Trend (SEC EDGAR, last 5y)

Revenues vs Net Income (last 5y)

FY endRevenuesOpIncome NetIncomeAssetsLiabilities EquityOCF
Dec 2025 28,000 -13,484,000 -14,290,000 29,719,000 12,684,000 -11,364,000
Dec 2024 0 -15,252,000 -13,004,000 18,236,000 10,235,000 -12,683,000
Dec 2023 651,000 -16,889,000 -18,397,000 20,395,000 6,290,000 -17,492,000
Dec 2022 0 -20,352,000 47,755,000 47,487,000 25,673,000 -28,331,000
Dec 2021

TTM Snapshot

Revenues TTM
NetIncome TTM
OpCashFlow TTM
Assets (Latest)
Forward EPS
$-0.25

Max Pain — expiry 2026-12-18

max pain strike: $1.00 · spot: $0.80 · call oi: 2,965 · put oi: 533
Expected Move to 2026-12-18: ±$1.00 (125.00%) — implied range $-0.20$1.80 · ATM straddle on $1.00 strike

Peers — same industry

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MIRA MIRA PHARMACEUTICALS, INC. $40.93M $0.97
ZYBT Zhengye Biotechnology Holding Ltd $40.75M $0.86
ATOS ATOSSA THERAPEUTICS, INC. $42.63M $4.95
KALA KALA BIO, Inc. $40.34M $2.17

News headlines (Yahoo Finance, 1h cache)

Talphera, Inc. Q1 2026 Earnings Call Summary
2026-05-14 12:30 · Yahoo
Talphera Inc (TLPH) Q1 2026 Earnings Call Highlights: Strong NEFRO Study Progress Amid Rising ...
2026-05-14 05:02 · Yahoo
Talphera Q1 2026 Earnings Call Transcript
2026-05-13 21:40 · Yahoo
Talphera (TLPH) Q1 2026 Earnings Transcript
2026-05-13 21:37 · Yahoo
Talphera Announces First Quarter 2026 Financial Results and Provides Corporate Update
2026-05-13 20:05 · Yahoo
Talphera to Host First Quarter Financial Results and Corporate Update Call and Webcast on Wednesday, May 13, 2026
2026-05-07 20:05 · Yahoo
Talphera Announces Two Abstracts Accepted for Presentation at AKI & CRRT 2026
2026-03-25 12:30 · Yahoo
Talphera: Q4 Earnings Snapshot
2026-03-23 12:44 · Yahoo
Talphera Announces Fourth Quarter and Full Year 2025 Financial Results and Provides Corporate Update
2026-03-23 12:30 · Yahoo
Talphera to Host Virtual Investor & Analyst Event to Discuss Niyad® for Use in Continuous Renal Replacement Therapy (CRRT), on March 23, 2026
2026-03-18 20:05 · Yahoo

Recent Insider Activity

No insider activity indexed for this ticker.